More than 340 stranded Canadian citizens and permanent residents left Dhaka for Toronto on Sunday.
The Qatar Airways flight, the third special flight organised by the Canadian high commission, will reach Toronto via Doha.
To date, the three flights have allowed over 760 stranded Canadians to return home, with all passengers expected to pay or reimburse their tickets, said the High Commission.
The Canadian high commission is assessing whether there is enough demand for a fourth and final assisted flight from Bangladesh to Canada.
The high commission said Canada is grateful to all government authorities involved as well as Qatar Airways for their continued support.