- Science to the fore -
"We're entering the Golden Age of ISS utilization," David Parker, director of human and robotic at the European Space Agency (ESA).
It was former president Ronald Reagan who invoked America's "pioneer spirit" when he directed NASA to "develop a permanently manned space station."
The first components were sent into space in 1998, while the first crew spent several months there in 2000.
The latest pressurized module was fitted in 2011, leaving the enormous artificial satellite 357 feet (109 meters) end-to-end, about the size of an American football field.
"For the first half of the space station's life, most of the focus was on building it," Robert Pearlman, a space historian and author of "Space Stations: The Art, Science, and Reality of Working in Space" told AFP.
Now, astronauts still need to work on maintenance jobs, "but the majority of their time is spent on performing hundreds of science investigations," he added.
More than 3,000 experiments have been carried out in this microgravity laboratory, which flies at an average of 248 miles (400 kilometers) above Earth, at 17,500 mph (28,000 km/h).
- What next? -
The immediate future of the ISS is officially assured until 2024 by the United States, Russia, Europe, Japan and Canada.
"From a technical standpoint, we have cleared ISS to fly until the end of 2028," NASA told AFP in a statement. "Additionally, our analysis has not identified any issues that would preclude us from extending beyond 2028 if needed."
Montalbano told AFP he plans later this year to start an analysis for the 2028-2032 period.
The use of the space station is expected to evolve.
NASA, which wants to disengage financially to focus on its deep space exploration with its Moon to Mars missions, announced in 2019 it would welcome paying tourists aboard the ISS to help offset costs.
They'll hitch a ride with SpaceX or Boeing -- whose own taxi program, "Starliner," is lagging behind schedule.
"My hope is that we fly the first private astronaut mission in 2022," Montalbano told AFP.
Competitors are also on the horizon.
Private company Axiom Space wants to build the world's first commercial space station -- first by attaching its modules to the ISS, before eventually detaching and commencing orbit by itself.
China plans to start work on its own big space station, Tiangong, this year and hopes to complete it by 2022.
Russia and China last week unveiled plans for a joint lunar station, "on the surface and/or in the orbit of the Moon," starting a new space alliance.
The move came after Moscow declined to participate in Gateway, NASA's proposed lunar station.
It could then be a fitting symbol of the end of decades' long US-Russia space partnership when the ISS is finally de-orbited and plunges into an ocean.