Arsenal took control of the battle to finish in the Premier League top four with a 3-1 win over Manchester United to all but end the Red Devils' hopes of Champions League football next season.
Nuno Tavares, Bukayo Saka and Granit Xhaka struck for Mikel Arteta's men to move them three points clear of Tottenham, who face Brentford later on Saturday.
Sixth-placed United are six points adrift of the top four and could miss out on European football completely next season.
Cristiano Ronaldo scored his 22nd goal of the season on his return to the United side after missing Tuesday's 4-0 thrashing at Liverpool due to the death of his newborn son.
Arsenal took control of the battle to finish in the Premier League top four with a 3-1 win over Manchester United to all but end the Red Devils' hopes of Champions League football next season.
Nuno Tavares, Bukayo Saka and Granit Xhaka struck for Mikel Arteta's men to move them three points clear of Tottenham, who face Brentford later on Saturday.
Sixth-placed United are six points adrift of the top four and could miss out on European football completely next season.
Cristiano Ronaldo scored his 22nd goal of the season on his return to the United side after missing Tuesday's 4-0 thrashing at Liverpool due to the death of his newborn son.
Maguire has been the target for much of the criticism directed at United this season, but the defence was no better in his absence.
It took just two minutes for the visitors' to be breached as David de Gea's fine save from Saka's initial effort counted for nothing as Tavares swept home the rebound.
There was another show of support for Ronaldo as just as at Anfield in midweek the entire stadium applauded during the seventh minute.
On the field, the Portuguese was receiving little help from his teammates.
De Gea stood up well to parry a piledriver from Eddie Nketiah from close range.
Seconds later, Nketiah found the net from another one-on-one.
A VAR review found the England under-21 international offside, but Saka was fouled by Alex Telles as he played the ball into Nketiah's path.
Saka took responsibility to send De Gea the wrong way from the penalty spot to double Arsenal's lead.
Ronaldo hit back within two minutes as he swept home Nemanja Matic's cross for his 100th Premier League goal.
Arsenal's nerves began to show and United should have been at least level by the time Xhaka fired home the final blow.
Tavares needlessly handled a corner into the Arsenal box on the hour.
Ronaldo stood aside to let Fernandes take the penalty, but his compatriot rolled the ball onto the post.
Moments later, Ronaldo had the ball in the net thanks to another smart, instinctive finish but was flagged offside.
Ronaldo then played provider for Diogo Dalot's shot to be turned onto the post by Aaron Ramsdale.
Arsenal had lost three consecutive games prior to a much-needed 4-2 win at Chelsea in midweek revived their top-four ambitions.
The relief around the Emirates was palpable when Xhaka restored the two-goal cushion with a powerful shot that flew past De Gea from 25 yards.