"I just want to have the opportunity to compete against the best players in the world and perform before one of the best crowds in the world," Djokovic said this week, as his fate hung in the balance.
It has thrown a dark cloud over the Slam for a second year in a row, after it was hit in 2021 by coronavirus.
Back then, top stars including Djokovic were forced to spend two weeks in their hotel rooms as part of Australia's mandatory quarantine requirements, with many angry about it.
A resilient Djokovic emerged to win a record-extending ninth Australian Open title, while Naomi Osaka clinched the women's crown.
This time Djokovic has an even bigger task, with his former coach Boris Becker telling the BBC the top seed was "shell-shocked" by having to spend five days in immigration detention.
"Obviously his preparation is beyond bad. I don't think he's ever been in a worse position entering the week before a Grand Slam, but that's just the way it is," Becker said after speaking to him on Monday.
If he does play, Djokovic is sure to face hostility from crowds upset that he is able to compete unvaccinated in a city that went through one of the longest series of lockdowns anywhere in the world.
"The crowd will be difficult with him but with each match he starts, he will win the crowd and they will embrace him again," Becker said.
Australia's treatment of Djokovic has divided observers and angered the Serbian government, but most can agree that tennis is the loser.
The ATP, the governing body of men's tennis, called the affair "damaging on all fronts" and Britain's former world number one Andy Murray said Tuesday that a resolution was needed as soon as possible.
"It's the first match that I have played here or won here in over three years, and yes, this is where the situations like this are frustrating for players because I want to come off and talk about my tennis," he said after victory in a Sydney warm-up tournament.
But the 34-year-old Murray, a three-time Grand Slam champion, added that Djokovic also has "a few questions" to answer.
Covid and the highly infectious Omicron variant also stalk the Australian Open.
Australian crowd-pleaser Nick Kyrgios -- who said that "how we are handling Novak's situation is bad, really bad" -- has tested positive for the virus, throwing his participation into major doubt.
Several high-profile players, including Spanish great Rafael Nadal, US Open champion Emma Raducanu and Tokyo Olympic champion Belinda Bencic are only just now returning to action from the virus.
Serena Williams and Roger Federer were already missing from Melbourne as they manage their workloads into the twilight of two of tennis's greatest careers.
It is easy to forget there is actually some tennis happening.
Nadal, who showed few ill effects in winning the build-up Melbourne Summer Set on Sunday, is also chasing a 21st Slam title.
In the women's draw, world number one Ashleigh Barty is the overwhelming favourite to break through and win a Grand Slam on home soil for the first time.