Ballon d'Or winner Karim Benzema, who has missed a series of games for Real Madrid this season because of injury, is set for his first World Cup appearance since 2014.
Benzema was frozen out of the France team for five-and-a-half years due to his role in a blackmail scandal involving a sextape and his international teammate Mathieu Valbuena.
He was convicted for his role in that affair last year but by then he had returned to the France side, playing at Euro 2020 and in the team that won the UEFA Nations League.
Giroud is two goals away from equalling Thierry Henry's national record of 51 but has often been overlooked since Benzema's recall.
The former Arsenal and Chelsea forward, now with AC Milan, would become France's oldest outfield player at a World Cup.
"You know tonight, I made some people unhappy. I am well aware of that," Deschamps told TF1.
"I made 25 players happy, but they will... all want to be in the starting 11. But it won't be possible, but it's the strength of the group that will be more important."
Paris Saint-Germain centre-back Presnel Kimpembe was picked despite thigh and Achilles problems that have limited him to five appearances since the start of September.
Varane will have gone a month without playing by the time Les Bleus meet Australia in their opening game of the World Cup on 22 November.
"The two cases are different," said Deschamps. "Kimpembe has had a little worry but he'll be available for his club for the last league match on Sunday.
"Varane has a longer-term injury but he too could be available against Australia if everything goes well."
Deschamps has plenty of cover in central defence with William Saliba, Dayot Upamecano, Jules Kounde and Ibrahima Konate in the squad. Benjamin Pavard and Lucas Hernandez can also fill in there.
Mandanda, 37, took the place of AC Milan goalkeeper Mike Maignan, who has been hampered by a calf injury.
France are without first-choice midfield pair Paul Pogba and N'Golo Kante, leaving Aurelien Tchouameni and Adrien Rabiot as the probable starters.
They will be supported by Monaco's Youssouf Fofana, Real Madrid's Eduardo Camavinga and Marseille duo Jordan Veretout and Matteo Guendouzi.
Goalkeepers: Hugo Lloris (Tottenham Hotspur/ENG), Steve Mandanda (Rennes/FRA) and Alphonse Areola (West Ham United/ENG)
Defenders: Lucas Hernandez (Bayern Munich/GER), Theo Hernandez (AC Milan/ITA), Presnel Kimpembe (Paris Saint-Germain), Ibrahima Konate (Liverpool/ENG), Jules Kounde (Barcelona/ESP), Benjamin Pavard (Bayern Munich/GER), William Saliba (Arsenal/ENG), Raphael Varane (Manchester United/ENG) and Dayot Upamecano (Bayern Munich/GER)
Midfielders: Eduardo Camavinga (Real Madrid/ESP), Youssouf Fofana (Monaco), Matteo Guendouzi (Marseille), Adrien Rabiot (Juventus/ITA), Aurelien Tchouameni (Real Madrid/ESP) and Jordan Veretout (Marseille)
Forwards: Karim Benzema (Real Madrid/ESP), Kingsley Coman (Bayern Munich/GER), Ousmane Dembele (Barcelona/ESP), Olivier Giroud (AC Milan/ITA), Antoine Griezmann (Atletico Madrid/ESP), Kylian Mbappe (Paris Saint-Germain) and Christopher Nkunku (RB Leipzig/GER)