Built using its industry network and energy modelling tools, the IEA's roadmap lays out more than 400 milestones on the path to net-zero by mid-century.
These include "no new oil and gas fields approved for development" beyond projects that are already committed as of 2021.
It predicts "a sharp decline in fossil fuel demand, meaning that the focus for oil and gas producers switches entirely to output -- and emissions reductions -- from the operation of existing assets".
The roadmap also said that sales of new internal combustion engine passenger cars would have to end in 2035 and energy efficiency would need to improve four percent annually this decade -- around three times faster than the current trajectory.
With annual additions of solar and wind power reaching 630 and 390 gigawatts respectively by 2030, the IEA said that investment in renewables could put global GDP four percent higher by 2050 than it would be based on current trends.
By 2050, it said that renewables capacity and greater efficiency would see global energy demand drop about eight percent compared to today, even as two billion more people gained access to electricity.
Investment totalling around $40 billion a year -- around one percent of current energy sector investment -- is projected to hook hundreds of millions up to the global grid.
The IEA said that clean energy and access to clean cooking solutions could cut the number of premature deaths by 2.5 million a year by 2050.
Overall, fossil fuels are set to account for only around a fifth of energy supply by 2050, down from almost four fifths currently, the report showed.
Dave Jones, global lead at the energy think tank Ember, said Tuesday's assessment was "a complete turnaround of the fossil-led IEA from five years ago".
"This is truly a knife into the fossil fuel industry," he said.
Under a scenario where all current national net-zero pledges are met on time and in full, the IEA outlined a changing energy mix in the coming decades.
Oil demand is predicted to plateau at around 104 million barrels a day just after 2030, the report showed.
Gas use is likely to increase significantly in the stated pledges pathway, as is nuclear.
It also said that all inefficient coal power plants needed to close by 2030 in order to achieve net-zero by 2050.
"This will be a huge step-up in ambition for so many countries, especially China," said Jones.
"India and South Africa will need international assistance to meet this goal."
'Pandering to industry fears'
While most of the global CO2 reductions until 2030 in the net-zero pathway come from "technologies available today", the IEA said that around half of reductions by 2050 would be provided by "technologies that are currently only in demonstration or prototype phase".
These include direct air capture and storage of CO2 from the atmosphere, which it said could be "particularly impactful".
Teresa Anderson, climate policy coordinator at ActionAid International, said that the IEA's net-zero plan still relied too heavily on as-yet untested technology to remove carbon pollution.
"Any role of future technologies should be to replace fossil fuels, not justify their use," she told AFP.
"Given all the uncertainties and risks around long-shot technologies and land availability for bioenergy, the IEA would do better to focus on bringing emissions down to real zero, rather than using 'net' zero accounting to pander to the fossil fuel industry's fears of losing profits."