“Unfortunately, today’s (Thursday) MRI shows us that the recovery is not as favourable as we hoped and we unfortunately resolve to declare Sadio’s withdrawal from the World Cup,” Senegal team doctor Manuel Afonso told reporters.
The forward has been crucial to the recent success of Senegal, who are regarded as Africa’s best hope at the World Cup.
His absence will be a blow to their chances of advancing out of Group A, where they face the Netherlands on Monday before playing host nation Qatar and Ecuador.
Mane has been the team’s talisman, scoring the winning penalty at the Africa Cup of Nations final in Cameroon in February and six weeks later securing World Cup qualification. On both occasion they edged out Egypt on post-match penalties.
Mane, 30, has twice been named African Footballer of the Year.