After conducting preclinical research that suggested connections between dehydration and cardiac fibrosis, a hardening of the heart muscles, Dmitrieva and researchers looked for similar associations in large-scale population studies.
They started by analysing data from more than 15,000 adults, ages 45-66, who enrolled in the Atherosclerosis Risk in Communities (ARIC) study between 1987-1989 and shared information from medical visits over a 25-year period.
In selecting participants for their retrospective review, the scientists focused on those whose hydration levels were within a normal range and were not suffering from diabetes, obesity, or heart failure at the start of the study. Approximately 11,814 adults were included in the final analysis, and, of those, the researchers found 1,366 (11.56 per cent) later developed heart failure.
To assess potential links with hydration, the team assessed the hydration status of the participants using several clinical measures. Looking at levels of serum sodium, which increases as the body's fluid levels decrease, was especially useful in helping to identify participants with an increased risk for developing heart failure.
It also helped identify older adults with an increased risk for developing heart failure and left ventricular hypertrophy, an enlargement and thickening of the heart.
For example, adults with serum sodium levels starting at 143 milliequivalents per litre (mEq/L) -- a normal range is 135-146 mEq/L -- in midlife had a 39 per cent associated increased risk for developing heart failure compared to adults with lower levels. And for every 1 mEq/L increase in serum sodium within the normal range of 135-146 mEq/L, the likelihood of a participant developing heart failure increased by 5 per cent.
In a cohort of about 5,000 adults ages 70-90, those with serum sodium levels of 142.5-143 mEq/L at middle age were 62 per cent more likely to develop left ventricular hypertrophy. Serum sodium levels starting at 143 mEq/L correlated with a 102 per cent increased risk for left ventricular hypertrophy and a 54 per cent increased risk for heart failure.
Based on these data, the authors have concluded serum sodium levels above 142 mEq/L in middle age are associated with increased risks of developing left ventricular hypertrophy and heart failure later in life.
A randomized, controlled trial will be necessary to confirm these preliminary findings, the researchers said. However, these early associations suggest good hydration may help prevent or slow the progression of changes within the heart that can lead to heart failure.
"Serum sodium and fluid intake can easily be assessed in clinical exams and help doctors identify patients who may benefit from learning about ways to stay hydrated," said Manfred Boehm, M.D., who leads the Laboratory of Cardiovascular Regenerative Medicine.
Fluids are essential for a range of bodily functions, including helping the heart pump blood efficiently, supporting blood vessel function, and orchestrating circulation. Yet many people take in far less than they need, the researchers said.