The authors used data on 78,915 mother-child pairs who participated in the Japan Environment and Children's Study to examine whether mothers' exposure to disinfectants in the workplace was associated with an increased risk of a diagnosis of allergic diseases in their children when aged 3 years. The odds of children having asthma or eczema were significantly higher if their mothers used disinfectants one to six times a week compared with the odds in children of mothers who never used disinfectants.
There was an exposure-dependent relationship between prenatal exposure to disinfectants and the odds of children experiencing these allergic conditions, with the children of mothers exposed to disinfectants every day having the highest odds of a diagnosis - 26 per cent greater for asthma and 29 per cent greater for eczema than children of mothers who were never exposed to disinfectants.
There were no significant associations between disinfectant use and food allergies. This is an observational study, and as such, can't establish a cause. The authors also noted some limitations, including that the information on disinfectant use by mothers was self-reported with specific disinfectants not identified. Diagnoses of allergic diseases in children were also reported by mothers. Nevertheless, the authors said, "Our findings indicate that exposure (to disinfectants) during pregnancy exerts an effect on allergies in offspring regardless of whether the mother returns to work when the child is 1 year old, and suggest an effect by exposure during pregnancy alone.
"They added, "Given the current increased use of disinfectants to prevent new coronavirus infections, it is of great public health importance to consider whether prenatal disinfectant exposure is a risk for the development of allergic diseases."
Several mechanisms that could explain the increased risk of allergic disease in children following their mothers' exposure to disinfectants during pregnancy were suggested by the authors.
They included microbiome-mediated (disinfectants impact the gut and skin microflora of the mother and subsequently the child), immune-mediated (exposure to some chemical compounds during pregnancy impacts the immune response in the foetus), postnatal exposure (children inhaled or touched molecules of disinfectant on the skin of their mothers), or bias (mothers who use medical disinfectants frequently are likely to be more medically knowledgeable and have better access to healthcare).