"Building on our shared democratic values and economic relationship — the world's largest — we look forward to working together to ensure trade and technology policies deliver for our people," Horne said.
The United States and EU in June declared a truce in a 17-year trade war over state subsidies for US planemaker Boeing and European rival Airbus, citing the bigger threat emanating from China's massive state subsidies to try to develop its own rival passenger aircraft.
The agreement reflected progress, but the underlying trade relationship between the two sides remains fragile and they remain at odds over Washington's punitive tariffs related to steel and aluminum.
The US co-chairs - secretary of state Antony Blinken, commerce secretary Gina Raimondo, and United States trade representative Katherine Tai - will host European Commission executive vice presidents Margrethe Vestager and Valdis Dombrovskis for the first council meeting in Pittsburgh.
The city, once a key center of the US steel industry, has reinvented itself as a hub for technology and cutting-edge industry through investments in its workers, while building ties with European partners.
The new council's 10 working groups will tackle issues ranging from technology standards, supply chain security, climate and green technology, data governance and competitiveness, as well as human rights and export controls, Horne said.
She said both governments were committed to a "robust and ongoing engagement" with a range of parties to ensure that the cooperation resulted in broad-based growth in both economies.