"This has been driven largely by the circadian rhythm field. But we in the nutrition field have wondered how this could be possible. Where would the energy go? We decided to take a closer look at how time of day interacts with metabolism,” Johnstone added.

In this study, the investigators recruited healthy subjects who were overweight or obese to have their diets controlled and their metabolisms measured over a period of time; 16 men and 14 women completed the study. Each participant was randomly assigned to eat either a morning-loaded or an evening-loaded diet for four weeks.

The diets were isocaloric, with a balance of 30 per cent protein, 35 per cent carbohydrate, and 35 per cent fat. After a washout period of one week in which calories were balanced throughout the day, each participant crossed over to the opposite diet for four weeks. In that way, each participant acted as their own study control.

Throughout the study, the subjects' total daily energy expenditures were measured using the doubly labeled water method, an isotope-based technique that looks at the difference between the turnover rates of the hydrogen and oxygen of body water as a function of carbon dioxide production.

The primary endpoint of the study was energy balance measured by body weight. Overall, the researchers found that energy expenditures and total weight loss were the same for the morning-loaded and evening-loaded diets. The subjects lost an average of just over 3 kg (about 7 pounds) during each of the four-week periods.

The secondary end points were subjective appetite control, glycemic control, and body composition. "The participants reported that their appetites were better controlled on the days they ate a bigger breakfast and that they felt satiated throughout the rest of the day,"

Johnstone says. "This could be quite useful in the real-world environment, versus in the research setting that we were working in."

One limitation of the study is that it was conducted under free-living conditions rather than in the lab. Additionally, certain metabolic measurements were available only after breakfast and not after dinner.

The author notes that this type of experiment could be applied to the study of intermittent fasting (also called time-restricted eating), to help determine the best time of day for people following this type of diet to consume their calories.

The group plans to expand its research into how the time of day affects metabolism by conducting studies similar to the one described here in subjects who do shift work. It's possible these individuals could have different metabolic responses due to the disruption of their circadian rhythms.

"One thing that's important to note is that when it comes to timing and dieting, there is not likely going to be one diet that fits all," Johnstone concludes. "Figuring this out is going to be the future of diet studies, but it's something that's very difficult to measure."

Read more from Well-being
Post Comment