Boris Johnson said on Thursday he was resigning as Britain's prime minister, bowing to calls from ministerial colleagues and lawmakers in his Conservative Party.
Below are some reactions:
"It is good news for the country that Boris Johnson has resigned as Prime Minister.
"But it should have happened long ago. He was always unfit for office. He has been responsible for lies, scandal and fraud on an industrial scale."
"I was Team Boris, as the GE (general election) showed he was our star player who connected across traditional political divides. Yes there were ups and downs, but he turbo-charged social mobility and opportunity.
"His resignation was inevitable. As a Party we must quickly unite and focus on what matters. These are serious times on many fronts."
"What a depressing state of affairs. So much needless damage caused.
"We now need a new Leader as soon as practicable. Someone who can rebuild trust, heal the country, and set out a new, sensible and consistent economic approach to help families.
"The wheels of Government must continue in the meantime."
"As well as resigning as Party leader the PM must resign his office. After losing so many ministers, he has lost the trust and authority required to continue. We need an acting PM who is not a candidate for leader to stabilise the government while a new leader is elected."
"We need Ministers back at their desks.
"Now PM has finally done the decent thing he needs to hand in the seals of office, apologise to Her Majesty, allow her to appoint a Caretaker under whom Ministers can serve, so the Conservative Party can choose a new leader properly."
"Relief basically. And also sadness at a missed opportunity. A man destroyed by his own fundamental flaws."
Ruth Davidson, member of House of Lords and former Scottish Conservative Party leader
"There's no way he can stay on until October. It's arrant nonsense to think he can. Someone needs to grip this."
"There will be a widespread sense of relief that the chaos of the last few days (indeed months) will come to an end, though notion of Boris Johnson staying on as PM until autumn seems far from ideal, and surely not sustainable?"
"It has been an utter absurdity that the people here have been subjected to Boris Johnson for any length of time. He is a figure of absolute disrepute. Anyone who tries to sabotage our peace agreements, a quarter century of progress and our shared future is truly no friend of ours."
"From our point of view, the political developments do not change our position on the (Northern Ireland) protocol or the way in which we work with our British counterparts on Northern Ireland.
"Our position is that we should endeavour to seek solutions as regards to the implementation of the protocol."
"He doesn't like us, we don't like him either."
"Boris Johnson was hit by a boomerang launched by himself ... His comrades-in-arms turned him in."
Zakharova said Johnson's fall was a symptom of the decline of the West, which she said was riven by political, ideological and economic crisis.
"The moral of the story is: do not seek to destroy Russia ... Russia cannot be destroyed. You can break your teeth on it - and then choke on them."